Bufavirus Protoparvovirus in feces of wild rats in China
- 24 November 2015
- journal article
- research article
- Published by Springer Science and Business Media LLC in Virus Genes
- Vol. 52 (1), 130-133
- https://doi.org/10.1007/s11262-015-1262-1
Abstract
Bufavirus (BuV) was first discovered from feces of children with acute diarrhea. It was subsequently detected from several animal species including shrews, bats, and nonhuman primates. In this study, we identified a novel Protoparvovirus, designated RatBuV, from the intestinal contents of wild rats using viral metagenomics. The near complete genome was 4643 nt encoding NS1, VP1, and VP2 proteins. Phylogenetic analysis over the complete genome showed that RatBuV clustered with Mpulungu BuV from shrews. Sequence analysis indicated that the putative protein sequences of NS1, VP1, and VP2 of RatBuV shared identities of 50.6–77.2, 48.3–77.3, and 47.1–78.3 %, respectively, with those of human BuVs, MpBuV, and WUHARV parvovirus, suggesting RatBuV belongs to a new species of Protoparvovirus. Our epidemiologic study indicated that the prevalence rate of RatBuV in the cohort of 40 wild rats is 12.5 % (5/40), which is higher than that of BuV in humans in a previous study.Keywords
Funding Information
- The Natural Science Foundation of Jiangsu Province (BK20130502, BK20140537)
- The National Natural Science Foundation of China (31302107)
- the Professional Research Foundation for Advanced Talents of Jiangsu University (12JDG085, 13JDG087, 13JDG025)
- China Postdoctoral Special Foundation (2015T80503)
- the Postdoctoral Foundation of Jiangsu Province (1302058C)
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