Noninfectious Serious Hazards of Transfusion
Top Cited Papers
- 1 March 2009
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Anesthesia & Analgesia
- Vol. 108 (3), 759-769
- https://doi.org/10.1213/ane.0b013e3181930a6e
Abstract
As infectious complications from blood transfusion have decreased because of improved donor questionnaires and sophisticated infectious disease blood screening, noninfectious serious hazards of transfusion (NISHOTs) have emerged as the most common complications of transfusion. The category of NISHOTs is very broad, including everything from well-described and categorized transfusion reactions (hemolytic, febrile, septic, and allergic/urticarial/anaphylactic) to lesser known complications. These include mistransfusion, transfusion-related acute lung injury, transfusion-associated circulatory overload, posttransfusion purpura, transfusion-associated graft versus host disease, microchimerism, transfusion-related immunomodulation, alloimmunization, metabolic derangements, coagulopathic complications of massive transfusion, complications from red cell storage lesions, complications from over or undertransfusion, and iron overload. In recent years, NISHOTs have attracted more attention than ever before, both in the lay press and in the scientific community. As the list of potential complications from blood transfusion grows, investigators have focused on the morbidity and mortality of liberal versus restrictive red blood cell transfusion, as well as the potential dangers of transfusing "older" versus "younger" blood. In this article, we review NISHOTs, focusing on the most recent concerns and literature.This publication has 93 references indexed in Scilit:
- Multiple Alloantibodies after Transfusion in an Infant Treated with InfliximabThe New England Journal of Medicine, 2007
- S -nitrosohemoglobin deficiency: A mechanism for loss of physiological activity in banked bloodProceedings of the National Academy of Sciences of the United States of America, 2007
- Evolution of adverse changes in stored RBCsProceedings of the National Academy of Sciences of the United States of America, 2007
- Prevention of red cell alloimmunization by CD25 regulatory T cells in mouse modelsAmerican Journal of Hematology, 2007
- Transfusion and the lung: circulatory overload and acute lung injuryVox Sanguinis, 2004
- Transfusion triggers: A systematic review of the literatureTransfusion Medicine Reviews, 2002
- ‘Near‐miss’ hyperkalaemic cardiac arrest associated with rapid blood transfusionAnaesthesia, 1999
- The Role of Blood from HLA-Homozygous Donors in Fatal Transfusion-Associated Graft-versus-Host Disease after Open-Heart SurgeryThe New England Journal of Medicine, 1989
- Post‐transfusion purpura: A report of five patients and a review of the pathogenesis and managementAmerican Journal of Hematology, 1986
- High-Dose Intravenous Immunoglobulin for Post-Transfusion PurpuraThe New England Journal of Medicine, 1983