Smoking and risk of glioma: a meta-analysis
- 1 July 2009
- journal article
- research article
- Published by Springer Science and Business Media LLC in Cancer Causes & Control
- Vol. 20 (10), 1927-1938
- https://doi.org/10.1007/s10552-009-9386-z
Abstract
Although causal relationships between smoking and cancer risk have been established for many sites, most studies of brain cancer have not supported an association. However, two recent cohort studies showed increased risks of glioma among smokers. We quantified the association between smoking and glioma through a meta-analysis of the literature. Of 20 eligible studies, 17 (6 cohort and 11 case–control) were included in an analysis of ever versus never smoking. Multivariate-adjusted risk estimates in the papers were pooled to calculate cumulative risk. The cumulative estimated risk associated with ever smoking was 1.06 (95% CI: 0.97–1.15), for all, 1.10 (95% CI: 1.01–1.20) for cohort, and 1.00 (95% CI: 0.88–1.15) for case–control studies. A significantly increased risk associated with past smoking was noted for cohort studies, OR = 1.16 (p = 0.007), while an increased risk of borderline significance was seen for all studies, OR = 1.10 (p = 0.08). In general, dose–response analysis did not support an association and was limited because very few studies included these variables and could be pooled. Overall, results of pooling of all studies suggested that smoking is not associated with risk of glioma. However, the small but significant increased risk seen for cohort studies remains to be clarified.Keywords
This publication has 54 references indexed in Scilit:
- Lifestyle factors and primary glioma and meningioma tumours in the Million Women Study cohortBritish Journal of Cancer, 2008
- Prospective study of cigarette smoking and adult glioma: Dosage, duration, and latencyNeuro-Oncology, 2007
- Cigarette smoking and risk of glioma: A prospective cohort studyInternational Journal of Cancer, 2005
- A review: dietary and endogenously formed N-nitroso compounds and risk of childhood brain tumorsCancer Causes & Control, 2005
- The Risk for Malignant Primary Adult-Onset Glioma in a Large, Multiethnic, Managed-Care Cohort: Cigarette Smoking and Other Lifestyle BehaviorsJournal of Neuro-Oncology, 2004
- Epidemiology of brain tumors in childhood—a reviewToxicology and Applied Pharmacology, 2004
- Risk Factors for Glioma in Adults: A Case-Control Study in Northeast ChinaCancer Detection Prevention, 1998
- Dietary and other lifestyle factors of women with brain gliomas in Los Angeles County (California, USA)Cancer Causes & Control, 1997
- Dietary and tobacco risk factors for adult onset glioma in the San Francisco Bay Area (California, USA)Cancer Causes and Control, 1997
- Risk Factors for Tumors of the Brain and Cranial Meninges in Seventh-Day AdventistsNeuroepidemiology, 1989