Bridging the translational divide: identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene
Open Access
- 1 October 2015
- journal article
- Published by Springer Science and Business Media LLC in Scientific Reports
- Vol. 5 (1), 14613
- https://doi.org/10.1038/srep14613
Abstract
Development of effective therapies for brain disorders has been hampered by a lack of translational cognitive testing methods. We present the first example of using the identical touchscreen-based cognitive test to assess mice and humans carrying disease-related genetic mutations. This new paradigm has significant implications for improving how we measure and model cognitive dysfunction in human disorders in animals, thus bridging the gap towards effective translation to the clinic.Keywords
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