Epidemiological transition of colorectal cancer in developing countries: Environmental factors, molecular pathways, and opportunities for prevention
- 1 January 2014
- journal article
- review article
- Published by Baishideng Publishing Group Inc. in World Journal of Gastroenterology
- Vol. 20 (20), 6055-72
- https://doi.org/10.3748/wjg.v20.i20.6055
Abstract
Colorectal cancer (CRC) is one of the leading causes of cancer and cancer-related mortality worldwide. The disease has been traditionally a major health problem in industrial countries, however the CRC rates are increasing in the developing countries that are undergoing economic growth. Several environmental risk factors, mainly changes in diet and life style, have been suggested to underlie the rise of CRC in these populations. Diet and lifestyle impinge on nuclear receptors, on the intestinal microbiota and on crucial molecular pathways that are implicated in intestinal carcinogenesis. In this respect, the epidemiological transition in several regions of the world offers a unique opportunity to better understand CRC carcinogenesis by studying the disease phenotypes and their environmental and molecular associations in different populations. The data from these studies may have important implications for the global prevention and treatment of CRC.Keywords
This publication has 100 references indexed in Scilit:
- Primary Prevention of Colorectal CancerGastroenterology, 2010
- Diet, physical activity, and body size associations with rectal tumor mutations and epigenetic changesCancer Causes & Control, 2010
- n -3 Polyunsaturated fatty acids modulate carcinogen-directed non-coding microRNA signatures in rat colonCarcinogenesis: Integrative Cancer Research, 2009
- Tumor markers and rectal cancer: Support for an inflammation‐related pathwayInternational Journal of Cancer, 2009
- Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: Studies with sulforaphane and garlic organosulfur compoundsEnvironmental and Molecular Mutagenesis, 2009
- Coordination of inflammation and metabolism by PPAR and LXR nuclear receptorsCurrent Opinion in Genetics & Development, 2008
- LXR Signaling Couples Sterol Metabolism to Proliferation in the Acquired Immune ResponseCell, 2008
- Farnesoid X receptor antagonizes nuclear factor κB in hepatic inflammatory responseJournal of Hepatology, 2008
- Dietary histone deacetylase inhibitors: From cells to mice to manSeminars in Cancer Biology, 2007
- Dietary Patterns and Risk of Colorectal Tumors: A Cohort of French Women of the National Education System (E3N)American Journal of Epidemiology, 2006