Live and let die: Hydrogen peroxide production by the commensal flora and its role in maintaining a symbiotic microbiome

Abstract

The majority of commensal oral streptococci are able to generate hydrogen peroxide (H₂O₂) during aerobic growth, which can diffuse through the cell membrane and inhibit competing species in close proximity. Competing H₂O₂ production is mainly dependent upon the pyruvate oxidase, SpxB and to a lesser extent the lactate oxidase LctO, both of which are important for energy generation in aerobic environments. Several studies point to a broad impact of H₂O₂ production in the oral environment, including a potential role in biofilm homeostasis, signaling, and interspecies interactions. Here, we summarize the current research regarding oral streptococcal H₂O₂ generation, resistance mechanisms, and the ecological impact of H₂O₂ production. We also discuss the potential therapeutic utility of H₂O₂ for the prevention/treatment of dysbiotic diseases as well as its potential role as a biomarker of oral health.