C-Reactive Protein and All-Cause Mortality in a Large Hospital-Based Cohort
Open Access
- 1 February 2008
- journal article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 54 (2), 343-349
- https://doi.org/10.1373/clinchem.2007.091959
Abstract
Background: C-reactive protein (CRP), an acute-phase protein, is a sensitive systemic marker of inflammation and acute-phase reactions. Testing CRP concentrations at hospital admission may provide information about disease risk and overall survival. Methods: All first-ever transmittals to the department of medical and chemical laboratory diagnostics for determination of low-sensitivity CRP (n = 274 515, 44.5% male, median age 51 years) between January 1991 and July 2003 were included [median follow-up time: 4.4 years (interquartile range, 2.3–7.4 years)]. The primary endpoint was all-cause mortality. Multivariate Cox regression adjusted for sex and age was applied for analysis. Results: Compared to individuals within the reference category (CRP 80 mg/L, all P 60 years: 1.7–3.7). Interestingly, both short- and long-term mortality were associated with increasing CRP concentrations (>80 mg/L: HR 22.8 vs 1.4). Conclusion: Measurement of low-sensitivity CRP at hospital admission allowed for the identification of patients at increased risk of unfavorable outcome. Our findings indicate that close attention should be paid to hospitalized patients with high CRP not only because of very substantial short-term risk, but also long-term excess risk, the basis for which needs to be determined.Keywords
This publication has 23 references indexed in Scilit:
- C-Reactive Protein Concentrations and Subsequent Ovarian Cancer RiskObstetrics & Gynecology, 2007
- CRP and the disposal of dying cells: Consequences for systemic lupus erythematosus and rheumatoid arthritisAutoimmunity, 2007
- Depressive symptoms and C-reactive protein: The Cardiovascular Risk in Young Finns StudyPsychological Medicine, 2006
- Plasma C-Reactive Protein and Risk of Colorectal Cancer in a Nested Case-Control Study: Japan Public Health Center–Based Prospective StudyCancer Epidemiology, Biomarkers & Prevention, 2006
- Race and Gender Differences in C-Reactive Protein LevelsJournal of the American College of Cardiology, 2005
- C-Reactive Protein, the Metabolic Syndrome, and Risk of Incident Cardiovascular EventsCirculation, 2003
- Markers of Inflammation and Cardiovascular DiseaseCirculation, 2003
- End-stage renal disease, atherosclerosis, and cardiovascular mortality: Is C-reactive protein the missing link?Kidney International, 2001
- C-Reactive Protein Frequently Colocalizes With the Terminal Complement Complex in the Intima of Early Atherosclerotic Lesions of Human Coronary ArteriesArteriosclerosis, Thrombosis, and Vascular Biology, 1998
- Metabolic and scintigraphic studies of radioiodinated human C-reactive protein in health and disease.JCI Insight, 1993