Allergic respiratory disease: Different allergens, different symptoms
- 16 February 2017
- Vol. 72 (9), 1306-1316
- https://doi.org/10.1111/all.13141
Abstract
Background Spanish population is rather homogeneous in its genetic and sociocultural characteristics, but allergen sensitization shows wide geographical variations. We aimed at assessing whether sensitization to different allergens in the diverse geographical areas induced different clinical and quality‐of‐life characteristics in adult patients with a first‐time diagnosis of rhinitis and/or asthma. Methods Two sequential, identically designed studies were carried out to evaluate such associations (PERFILAR I and II). PERFILAR II was an extension of PERFILAR I with additional allergens being included. Both phases were epidemiological, descriptive, cross‐sectional, nonintervention multicenter studies. Participants were required to have lived for at least the last 2 years in the geographical zone. Asthma control assessment was based on ACQ‐5. Health‐related quality of life was evaluated with validated scales for rhinitis (ESPRINT‐15) and asthma (Mini‐AQLQ). Skin prick tests were used to identify sensitization to involved allergens. Results A total of 301 physicians recruited 2711 patients for PERFILAR I+II. Sensitization to allergens was significantly different in patients with rhinitis with/without asthma. Seasonal allergens were associated with rhinitis, a longer time to asthma development, and more severe and commonly intermittent rhinitis. HDM were associated with more common rhinitis, and Alternaria was associated with asthma. The study confirms an association of geographical areas with relevant allergens and allergic clinical picture. Conclusion Different types of aeroallergens and specific sensitization profiles are associated with different allergic clinical pictures (rhinitis with/without asthma), different clinical symptoms, and different levels of severity. This could have implications to predict later clinical course and to select appropriate management approaches.Keywords
This publication has 35 references indexed in Scilit:
- Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 RevisionJournal of Allergy and Clinical Immunology, 2010
- From atopic dermatitis to asthma: the atopic marchAnnals of Allergy, Asthma & Immunology, 2010
- Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*Allergy, 2008
- Treatment strategies for allergy and asthmaNature Reviews Immunology, 2008
- Geographic variations in the effect of atopy on asthma in the European Community Respiratory Health StudyJournal of Allergy and Clinical Immunology, 2004
- Prevalence and rate of diagnosis of allergic rhinitis in EuropeEuropean Respiratory Journal, 2004
- Rhinitis and asthma: Evidence for respiratory system integrationJournal of Allergy and Clinical Immunology, 2003
- The European Community Respiratory Health Survey IIEuropean Respiratory Journal, 2002
- Epidemiologic evidence for asthma and rhinitis comorbidityJournal of Allergy and Clinical Immunology, 2000
- The rising trends in asthma and allergic diseaseClinical and Experimental Allergy, 1998