Impairment of B-cell functions during HIV-1 infection
- 24 September 2013
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in AIDS
- Vol. 27 (15), 2323-2334
- https://doi.org/10.1097/qad.0b013e328361a427
Abstract
A variety of B-cell dysfunctions are manifested during HIV-1 infection, as reported early during the HIV-1 epidemic. It is not unusual that the pathogenic mechanisms presented to elucidate impairment of B-cell responses during HIV-1 infection focus on the impact of reduced T-cell numbers and functions, and lack of germinal center formation in lymphoid tissues. To our understanding, however, perturbation of B-cell phenotype and function during HIV-1 infection may begin at several different B-cell developmental stages. These impairments can be mediated by intrinsic B-cell defects as well as by the lack of proper T-cell help. In this review, we will highlight some of the pathways and molecular interactions leading to B-cell impairment prior to germinal center formation and B-cell activation mediated through the B-cell receptor in response to HIV-1 antigens. Recent studies indicate a regulatory role for B cells on T-cell biology and immune responses. We will discuss some of these novel findings and how these regulatory mechanisms could potentially be affected by the intrinsic defects of B cells taking place during HIV-1 infection.Keywords
This publication has 104 references indexed in Scilit:
- B cell depletion therapy ameliorates autoimmune disease through ablation of IL-6-producing B cellsThe Journal of Experimental Medicine, 2012
- Comprehensive Analysis of Frequency and Phenotype of T Regulatory Cells in HIV Infection: CD39 Expression of FoxP3+T Regulatory Cells Correlates with Progressive DiseaseJournal of Virology, 2011
- Effect of highly active antiretroviral therapy on biomarkers of B-lymphocyte activation and inflammationAIDS, 2011
- B-cell depletion reveals a role for antibodies in the control of chronic HIV-1 infectionNature Communications, 2010
- CD95 co-stimulation blocks activation of naive T cells by inhibiting T cell receptor signalingThe Journal of Experimental Medicine, 2009
- Timing of HAART defines the integrity of memory B cells and the longevity of humoral responses in HIV-1 vertically-infected childrenProceedings of the National Academy of Sciences of the United States of America, 2009
- Indications of Rituximab in autoimmune diseasesDrug Discovery Today: Therapeutic Strategies, 2009
- Evidence for a Pathogenic Determinant in HIV-1 Nef Involved in B Cell Dysfunction in HIV/AIDSCell Host & Microbe, 2008
- Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individualsThe Journal of Experimental Medicine, 2008
- Two overrepresented B cell populations in HIV-infected individuals undergo apoptosis by different mechanismsProceedings of the National Academy of Sciences of the United States of America, 2006