Broader Autism Phenotype in Parents of Children with Autism: A Systematic Review of Percentage Estimates
- 22 February 2018
- journal article
- review article
- Published by Springer Science and Business Media LLC in Journal of Child and Family Studies
- Vol. 27 (6), 1705-1720
- https://doi.org/10.1007/s10826-018-1026-3
Abstract
The broader autism phenotype (BAP) is a collection of sub-diagnostic autistic traits more common in families of individuals with autism spectrum disorder (ASD) than in the general population. BAP is a latent construct that can be defined using different domains, measured using multiple instruments, and reported using different techniques. Therefore, estimates of BAP may vary greatly across studies. Our objective was to systematically review studies that reported occurrence of BAP in parents of children with ASD in order to quantify and describe heterogeneity in estimates. We systematically searched PubMed and Scopus using PRISMA guidelines for studies quantifying percentage of parents of children with ASD who had BAP. We identified 41 studies that measured BAP in parents of children with ASD. These studies used eight different instruments, four different forms of data collection, and had a wide range of sample sizes (N = 4 to N = 3299). Percentage with BAP ranged from 2.6% to 80%. BAP was more prevalent in fathers than mothers. Parental BAP may be an important tool for parsing heterogeneity in ASD etiology and for developing parent-mediated ASD interventions. However, the variety in measurement instruments and variability in study samples limits our ability to synthesize estimates. To improve measurement of BAP and increase consistency across studies, universal methods should be accepted and adopted across studies. A more consistent approach to BAP measurement may enable efficient etiologic research that can be meta-analyzed and may allow for a larger evidence base that can be used to account for BAP when developing parent-mediated interventions.Keywords
Funding Information
- Autism Speaks (10052)
This publication has 90 references indexed in Scilit:
- Evidence for broader autism phenotype characteristics in parents from multiple‐incidence autism familiesAutism Research, 2011
- Narrowing the broader autism phenotypeAutism, 2010
- Can family affectedness inform infant sibling outcomes of autism spectrum disorders?Journal of Child Psychology and Psychiatry, 2010
- Neuropsychological Profile of Autism and the Broad Autism PhenotypeArchives of General Psychiatry, 2009
- Developmental course of autistic social impairment in malesDevelopment and Psychopathology, 2009
- Genome-wide Linkage Analyses of Quantitative and Categorical Autism SubphenotypesBiological Psychiatry, 2008
- Distinct Face-Processing Strategies in Parents of Autistic ChildrenCurrent Biology, 2008
- Familial aggregation of quantitative autistic traits in multiplex versus simplex autismNeuropsychiatric Genetics, Part B of the American Journal of Medical Genetics (AJMG), 2008
- Defining key features of the broad autism phenotype: A comparison across parents of multiple‐ and single‐incidence autism familiesNeuropsychiatric Genetics, Part B of the American Journal of Medical Genetics (AJMG), 2008
- The broader language phenotype of autism: a comparison with specific language impairmentJournal of Child Psychology and Psychiatry, 2007