Lifestyle intervention and/or statins for the reduction of C‐reactive protein in type 2 diabetes: From the look AHEAD study
Open Access
- 20 March 2013
- Vol. 21 (5), 944-950
- https://doi.org/10.1002/oby.20431
Abstract
Objective: Cardiovascular risk remains high despite statin use. Overweight/obese diabetic persons usually have normal/low LDL‐cholesterol but high C‐reactive protein (CRP) levels. We aimed to examine the effects of intensive lifestyle intervention for weight loss (ILI) on CRP levels in overweight/obese diabetic individuals by statin use. Design and Methods: Look AHEAD was a randomized trial in overweight/obese type 2 diabetic individuals testing whether ILI would reduce cardiovascular mortality, when compared to usual care. CRP changes in 1,431 participants with biomarker levels, who remained on or off statin treatment for 1 year, were evaluated. Results: The reduction in CRP levels with ILI at 1 year in men and women on statins was −44.9 and −42.3%, respectively, compared to −13.7 and −21.0% for those on statins and usual care (P < 0.0001). At 1 year, median CRP levels were: 1.8 mg L−1 in participants randomized to ILI on statin therapy; 2.6 mg L−1 for those on statins randomized to usual care and 2.9 mg L−1 for participants not on statins but randomized to ILI. Weight loss was associated with 1‐year CRP reduction (P < 0.0001) in statin and nonstatin users. Conclusions: Our findings suggest that in overweight/obese diabetic persons, ILI and statin therapy may have substantial additive anti‐inflammatory benefits.Keywords
Funding Information
- National Institute of Diabetes and Digestive and Kidney Diseases
- National, Heart, Lung and Blood Institute
- (NHLBI)
- National Institute of Nursing Research
- Office of Research on Women's Health
- National Center on Minority Health and Health Disparities
- Centers for Disease Control and Prevention (HL090514-02S1)
- (LMB) (HL090514)
- (CMB)
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