Biotransformation of BDE-47 to Potentially Toxic Metabolites Is Predominantly Mediated by Human CYP2B6
- 1 April 2013
- journal article
- Published by Environmental Health Perspectives in Environmental Health Perspectives
- Vol. 121 (4), 440-446
- https://doi.org/10.1289/ehp.1205446
Abstract
Background: Previous studies have indicated that cytochrome P450s (CYPs) are involved in the metabolism of polybrominated diphenyl ether (PBDE) flame retardants in humans, resulting in the formation of hydroxylated PBDEs (OH-PBDEs) that are potentially more toxic than the parent PBDEs. However, the specific enzymes responsible for the formation of OH-PBDEs are unknown.Keywords
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