Tobacco smoke particulate matter chemistry by NMR
- 11 December 2006
- journal article
- Published by Wiley in Magnetic Resonance in Chemistry
- Vol. 45 (2), 167-170
- https://doi.org/10.1002/mrc.1939
Abstract
The submicron liquid droplets constituting the particulate matter of mainstream tobacco smoke (PMMTS) are viscous and of a composition that is complex and poorly understood. PMMTS is often ∼80% w/w ‘tar’ where ‘tar’ = total PMMTS− (nicotine + water). Many of the chemical agents in MTS responsible for smoking‐related cancers are found at least partially in the PMMTS portion of MTS. The properties of PMMTS vary with brand and with puffing patterns. The chemical forms and total levels of nicotine, the identities/levels of other compositionally dominant compounds, and the identities/levels of carcinogens are of interest. Most studies of the composition of PMMTS have involved extraction then chromatography. Such methods allow the determination of low‐level constituents, but alter the samples such that direct information regarding chemical conditions within the PMMTS cannot be obtained. Here, we utilize nuclear magnetic resonance spectroscopy (NMR) to examine native PMMTS in conventional cigarettes, including measurements of the brand‐dependent fraction of PMMTS nicotine that is in the free‐base form (increasing this fraction in inhaled tobacco smoke affects the rates of the processes governing nicotine deposition in the respiratory tract, and so has implications for smoking behavior and addiction). We also demonstrate the use of NMR for characterizing the composition of PMMTS (including the levels of selected cigarette additives) when the cosolvent DMSO‐d6 is added to improve spectral resolution. The native and solvent‐assisted results open the door to a range of future studies. Copyright © 2006 John Wiley & Sons, Ltd.Keywords
This publication has 9 references indexed in Scilit:
- Mainstream smoke constituent yields and predicting relationships from a worldwide market sample of cigarette brands: ISO smoking conditionsRegulatory Toxicology and Pharmacology, 2004
- Tobacco carcinogens, their biomarkers and tobacco-induced cancerNature Reviews Cancer, 2003
- Development of a Method To Assess Cigarette Smoke IntakeEnvironmental Science & Technology, 2003
- Percent Free Base Nicotine in the Tobacco Smoke Particulate Matter of Selected Commercial and Reference CigarettesChemical Research in Toxicology, 2003
- Fraction of Free-Base Nicotine in Fresh Smoke Particulate Matter from the Eclipse “Cigarette” by 1H NMR SpectroscopyChemical Research in Toxicology, 2002
- Metabonomics: a platform for studying drug toxicity and gene functionNature Reviews Drug Discovery, 2002
- A Consideration of the Role of Gas/Particle Partitioning in the Deposition of Nicotine and Other Tobacco Smoke Compounds in the Respiratory TractChemical Research in Toxicology, 2001
- A New Perspective of Enthalpies of Proton Transfer of Aliphatic Amines, Hydroxyamines, and Aminoalkylsulfonic Acids in Methanol–Water Mixtures by Direct CalorimetryJournal of Solution Chemistry, 2001
- Sensitivity-enhanced two-dimensional heteronuclear shift correlation NMR spectroscopyJournal of Magnetic Resonance (1969), 1986