Adiponectin – journey from an adipocyte secretory protein to biomarker of the metabolic syndrome
- 17 January 2005
- journal article
- review article
- Published by Wiley in Journal of Internal Medicine
- Vol. 257 (2), 167-175
- https://doi.org/10.1111/j.1365-2796.2004.01426.x
Abstract
Adiponectin is an adipocyte-derived hormone that was discovered in 1995. Unlike leptin, which was identified around the same time, the clinical relevance of adiponectin remained obscure for a number of years. However, starting in 2001, several studies were published from different laboratories that highlighted the potential antidiabetic, antiatherosclerotic and anti-inflammatory properties of this protein complex. Methods to measure the protein with high throughput assays in clinical samples were developed shortly thereafter, and as a result hundreds of clinical studies have been published over the past 3 years describing the role of adiponectin in endocrine and metabolic dysfunction. Furthermore, adiponectin research has expanded to include a role for adiponectin in cancer and other disease areas. Although it is an impossible task to summarize the findings from all these studies in a single review, we aim to demonstrate the utility of circulating adiponectin as a biomarker of the metabolic syndrome. Evidence for this relationship will include how decreased levels of plasma adiponectin ('hypoadiponectinaemia') are associated with increased body mass index (BMI), decreased insulin sensitivity, less favourable plasma lipid profiles, increased levels of inflammatory markers and increased risk for the development of cardiovascular disease. Therefore, adiponectin levels hold great promise for use in clinical application serving as a potent indicator of underlying metabolic complications.Keywords
This publication has 70 references indexed in Scilit:
- Effects of rosiglitazone on gene expression in subcutaneous adipose tissue in highly active antiretroviral therapy-associated lipodystrophyAmerican Journal of Physiology-Endocrinology and Metabolism, 2004
- Adiponectin is reduced in gestational diabetes mellitus in normal weight womenActa Obstetricia et Gynecologica Scandinavica, 2004
- Complex Distribution, Not Absolute Amount of Adiponectin, Correlates with Thiazolidinedione-mediated Improvement in Insulin SensitivityJournal of Biological Chemistry, 2004
- Muscle insulin receptor concentrations in obese patients post bariatric surgery: relationship to hyperinsulinemiaInternational Journal of Obesity, 2004
- Plasma Adiponectin and Endogenous Glucose Production in HumansDiabetes Care, 2003
- Cloning of adiponectin receptors that mediate antidiabetic metabolic effectsNature, 2003
- Differences in Adiponectin Protein Expression: Effect of Fat Depots and Type 2 Diabetic StatusHormone and Metabolic Research, 2002
- Disruption of Adiponectin Causes Insulin Resistance and Neointimal FormationJournal of Biological Chemistry, 2002
- Hormonal Regulation of Adiponectin Gene Expression in 3T3-L1 AdipocytesBiochemical and Biophysical Research Communications, 2002
- Secretion of Adiponectin and Regulation of apM1 Gene Expression in Human Visceral Adipose TissueBiochemical and Biophysical Research Communications, 2001