Differences in Clinical Features According to Boryoung and Karp Genotypes of Orientia tsutsugamushi
Open Access
- 15 August 2011
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 6 (8), e22731
- https://doi.org/10.1371/journal.pone.0022731
Abstract
Scrub typhus is an infectious disease caused by Orientia tsutsugamushi. The differences in virulence of O. tsutsugamushi prototypes in humans are still unknown. We investigated whether there are any differences in the clinical features of the Boryoung and Karp genotypes. Patients infected with O. tsutsugamushi, as Boryoung and Karp clusters, who had visited 6 different hospitals in southwestern Korea were prospectively compared for clinical features, complications, laboratory parameters, and treatment responses. Infected patients in the Boryoung cluster had significantly more generalized weakness, eschars, skin rashes, conjunctival injection, high albumin levels, and greater ESR and fibrinogen levels compared to the Karp cluster. The treatment response to current antibiotics was significantly slower in the Karp cluster as compared to the Boryoung cluster. The frequency of occurrence of eschars and rashes may depend on the genotype of O. tsutsugamushi.Keywords
This publication has 26 references indexed in Scilit:
- Scrub Typhus: The Geographic Distribution of Phenotypic and Genotypic Variants ofOrientia tsutsugamushiClinical Infectious Diseases, 2009
- Genotyping ofOrientia tsutsugamushifrom Humans with Scrub Typhus, LaosEmerging Infectious Diseases, 2008
- Detection of new genotypes of Orientia tsutsugamushi infecting humans in ThailandClinical Microbiology & Infection, 2008
- Determination and geographic distribution of Orientia tsutsugamushi serotypes in Thailand by nested polymerase chain reactionDiagnostic Microbiology and Infectious Disease, 2006
- Acute Hearing Loss Due to Scrub Typhus: A Forgotten Complication of a Reemerging DiseaseClinical Infectious Diseases, 2006
- Rickettsialpox: Report of three cases and a reviewJournal of the American Academy of Dermatology, 2004
- Paediatric scrub typhus in Thailand: a study of 73 confirmed casesTransactions of the Royal Society of Tropical Medicine and Hygiene, 2004
- Phylogenetic analysis ofOrientia tsutsugamushistrains based on the sequence homologies of 56-kDa type-specific antigen genesFEMS Microbiology Letters, 1999
- Classification of Rickettsia tsutsugamushi in a New Genus, Orientia gen. nov., as Orientia tsutsugamushi comb. nov.International Journal of Systematic and Evolutionary Microbiology, 1995
- Scrub and murine typhus in children with obscure fever in the tropicsThe Pediatric Infectious Disease Journal, 1991