Cell-Surface Markers in Lymphoproliferative Disease

Abstract

THE study of lymphocyte-surface markers is central to cellular immunology and is a complex and rapidly changing field.^{1 , 2} Nonetheless, this is an appropriate time to review the knowledge derived from the conventional techniques of rosette formation and fluorescence microscopy with heteroantiserums while the field pauses before a new body of knowledge is generated with the development of monoclonal antibodies and laser technology (the fluorescence-activated cell sorter). This discussion is restricted to the application of lymphocyte-surface markers to lymphocytic leukemias and lymphomas — a clinical area in which these methods have been useful.^{3 , 4} At present, the existence of curative treatment for . . .