Computer Pattern Recognition: Spontaneous Motor Activity Studies of Rats Following Acute Exposure to Triethyltin

Abstract

A computer pattern recognition system, RAPID, was used to measure the spontaneous activity of male Sprague-Dawley rats during six observational periods distributed over 11 days after a single oral dose of triethyltin bromide (TET) at 3 or 5 mg/kg. These observational periods were distributed between those taken under red light conditions during the animals normal dark cycle (Days 2, 7, and 10 after exposure) and those taken under white light conditions during the animals normal light cycle (Days 3, 6, and 11 after exposure). Significant disruption of the normal behavioral patterns were observed on Days 2 and 7 for the 3 mg/kg-exposed group and on Days 2, 3, 6, 7, and 10 for the 5 mg/kg-exposed group.