Mapping out of catecholamine and 5-hydroxytryptamine neurons innervating the telencephalon and diencephalon

Abstract
In previous investigations a large nigro-neostriatal dopamine (DA) neuron system has been characterized (1, 2). Also the hypothalamus, the preoptic area and the limbic system are innervated by ascending catecholamine (CA) neuron systems which degenerate after destruction of the CA cell groups in the mesencephalon (3). In this paper additional experimental evidence for the presence of ascending CA and 5-hydroxytryptamine (5-HT) neuron systems from the lower brain stem will be given consisting of changes in amine levels after different types of lesions in the prosencephalon (telencephalon plus diencephalon).