Absence of a functional defect in CD8+ T cells during primary murine gammaherpesvirus-68 infection of I-Ab−/− mice
Open Access
- 1 February 2003
- journal article
- Published by Microbiology Society in Journal of General Virology
- Vol. 84 (2), 337-341
- https://doi.org/10.1099/vir.0.18821-0
Abstract
The murine gammaherpesvirus-68 kills I-Ab−/− mice despite the presence of virus-specific CD8+ cytotoxic T lymphocytes (CTL). This has raised the possibility that these CTL are functionally abnormal. Here, no difference was observed between I-Ab−/− mice and I-Ab+/+ controls in virus-specific CTL function, T cell receptor usage, or surface phenotype. Thus CTL immunity was independent of CD4+ T cells in a chronic herpesvirus infection, but was still inadequate to control virus replication.Keywords
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