Synthesis and Antimicrobial Properties of New 4‐(Alkylidene/arylidene)‐amino‐5‐(2‐furanyl)‐2,4‐dihydro‐3H‐1,2,4‐triazole‐3‐thiones and 6‐Aryl‐3‐(2‐furanyl)‐7H‐1,2,4‐triazolo[3,4‐b][1,3,4]thiadiazines
- 1 January 1996
- journal article
- research article
- Published by Wiley in Archiv der Pharmazie
- Vol. 329 (8-9), 427-430
- https://doi.org/10.1002/ardp.19963290811
Abstract
A series of 4-(alkylidene/arylidene)amino-5-(2-furanyl)-2,4-dihydro-3H-1,2,4-triazole-3-thiones (2) and 6-aryl-3-(2-furanyl)-7H-1,2,4-triazolo[3,4-b][1,3,4] thiadiazines (3) were synthesized. The configuration of 2g was assigned on the basis of 1H-NMR data. Of the new derivatives tested, only 2b, 2g, and 4f were found to be active against Staphylococcus aureus and/or Staphylococcus epidermidis (MIC 125–1.95 μg/ml), whereas all exhibited varying degrees of antifungal activity (MIC 25–0.8 μg/ml).Keywords
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