Somatic Frameshift Mutations in the BAX Gene in Colon Cancers of the Microsatellite Mutator Phenotype
- 14 February 1997
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 275 (5302), 967-969
- https://doi.org/10.1126/science.275.5302.967
Abstract
Cancers of the microsatellite mutator phenotype (MMP) show exaggerated genomic instability at simple repeat sequences. More than 50 percent (21 out of 41) of human MMP + colon adenocarcinomas examined were found to have frameshift mutations in a tract of eight deoxyguanosines [(G) 8 ] within BAX , a gene that promotes apoptosis. These mutations were absent in MMP − tumors and were significantly less frequent in (G) 8 repeats from other genes. Frameshift mutations were present in both BAX alleles in some MMP + colon tumor cell lines and in primary tumors. These results suggest that inactivating BAX mutations are selected for during the progression of colorectal MMP + tumors and that the wild-type BAX gene plays a suppressor role in a p53-independent pathway for colorectal carcinogenesis.Keywords
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