THE INFLUENCE OF SEROTONIN ON THE MITOTIC RATE IN THE COLONIC CRYPT EPITHELIUM AND IN COLONIC ADENOCARCINOMA IN RATS
- 1 February 1978
- journal article
- Published by Wiley in Clinical and Experimental Pharmacology and Physiology
- Vol. 5 (1), 91-94
- https://doi.org/10.1111/j.1440-1681.1978.tb00657.x
Abstract
1. The mitotic rate in the crypts of Lieberkühn of the descending colon and in dimethylhydrazine-induced adenocarcinomata of the descending colon of rat was measured using a stathmokinetic technique. 2. Intraperitoneal injection of a small dose (10 microgram/kg) of serotonin resulted in an increase in the tumour cell mitotic rate. 3. Blockade of serotonin receptors by 2-bromolysergic acid diethylamide and depletion of tissue serotonin levels following injection of DL-6-fluorotryptophan both result in a decrease in the tumour cell mitotic rate. 4. Treatment with serotonin, 2-bromolysergic acid diethylamide and DL-6-fluorotryptophan were all without effect on the colonic crypt cell mitotic rate.Keywords
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