Highly sensitive and selective sugar detection by terahertz nano-antennas
Open Access
- 23 October 2015
- journal article
- research article
- Published by Springer Science and Business Media LLC in Scientific Reports
- Vol. 5 (1), 15459
- https://doi.org/10.1038/srep15459
Abstract
Molecular recognition and discrimination of carbohydrates are important because carbohydrates perform essential roles in most living organisms for energy metabolism and cell-to-cell communication. Nevertheless, it is difficult to identify or distinguish various carbohydrate molecules owing to the lack of a significant distinction in the physical or chemical characteristics. Although there has been considerable effort to develop a sensing platform for individual carbohydrates selectively using chemical receptors or an ensemble array, their detection and discrimination limits have been as high in the millimolar concentration range. Here we show a highly sensitive and selective detection method for the discrimination of carbohydrate molecules using nano-slot-antenna array-based sensing chips which operate in the terahertz (THz) frequency range (0.5–2.5 THz). This THz metamaterial sensing tool recognizes various types of carbohydrate molecules over a wide range of molecular concentrations. Strongly localized and enhanced terahertz transmission by nano-antennas can effectively increase the molecular absorption cross sections, thereby enabling the detection of these molecules even at low concentrations. We verified the performance of nano-antenna sensing chip by both THz spectra and images of transmittance. Screening and identification of various carbohydrates can be applied to test even real market beverages with a high sensitivity and selectivity.This publication has 18 references indexed in Scilit:
- Terahertz Biomedical Science and TechnologyPublished by Informa UK Limited ,2014
- Detection of microorganisms using terahertz metamaterialsScientific Reports, 2014
- Surface plasmon resonance (SPR) sensors: approaching their limits?Optics Express, 2009
- Terahertz field enhancement by a metallic nano slit operating beyond the skin-depth limitNature Photonics, 2009
- Sensitive optical biosensors for unlabeled targets: A reviewAnalytica Chimica Acta, 2008
- Cutting-edge terahertz technologyNature Photonics, 2007
- Chemical recognition in terahertz time-domain spectroscopy and imagingSemiconductor Science and Technology, 2005
- Non-destructive terahertz imaging of illicit drugs using spectral fingerprintsOptics Express, 2003
- THz-Spectroscopy of Biological MoleculesJournal of Biological Physics, 2003
- Protein detection by optical shift of a resonant microcavityApplied Physics Letters, 2002