Insulin binding sites on the nuclear envelope: potential relationship to mRNA metabolism
- 1 January 1982
- journal article
- review article
- Published by Wiley in Journal of Cellular Biochemistry
- Vol. 20 (1), 29-39
- https://doi.org/10.1002/jcb.240200104
Abstract
Insulin regulates the growth and metabolism of most tissues. The hormonal potency of insulin results, to a large extent, from its ability to regulate target cells at a variety of subcellular sites. For many years, the effects of insulin on membrane transport, enzyme activity, and protein synthesis have been studied extensively. Less attention, however, was given to how insulin regulates nuclear functions. Recently the presence of specific binding sites for insulin on nuclei and nuclear envelopes have been documented and characterized. These binding sites have biochemical characteristics that are different from insulin binding sites on the plasma membrane. Moreover, direct in vitro effects of insulin on messenger RNA (mRNA) metabolism have recently been reported. These effects include the stimulation of mRNA efflux from intact nuclei, and stimulation of nucleoside triphosphatase activity (NTPase), the enzyme that regulates mRNA efflux. Thus, significant insight is now being gained concerning the action of insulin on the cell nucleus.Keywords
This publication has 43 references indexed in Scilit:
- Insulin Stimulation of Nucleoside Triphosphatase Activity in Isolated Nuclear EnvelopesScience, 1982
- Pancreatic Islet-Acinar Cell Interaction: Amylase Messenger RNA Levels Are Determined By InsulinScience, 1981
- Control of fatty acid synthetase mRNA levels in rat liver by insulin, glucagon, and dibutyl cyclic AMPBiochemical and Biophysical Research Communications, 1981
- Insulin as a Potent, Specific Growth Factor in a Rat Hepatoma Cell LineScience, 1981
- Incubation of exogenous fatty acids with lymphocytes. Changes in fatty acid composition and effects on the rotational relaxation time of 1,6-diphenyl-1,3,5-hexatrieneBiochemistry, 1980
- Insulin binding to isolated liver nuclei from obese and lean miceBiochemistry, 1979
- Insulin receptors and the site of action of insulinLife Sciences, 1978
- INSULIN BINDING TO RAT LIVER GOLGI FRACTIONSThe Journal of cell biology, 1973
- FRACTIONATION OF THE NUCLEUS BY DIVALENT CATIONSThe Journal of cell biology, 1972
- The Role of Insulin in the Regulation of α‐Amylase Synthesis in the Rat PancreasEuropean Journal of Clinical Investigation, 1972