Reactivity of N 1-Dithioester Substituted Pyridinand Pyrazincarboxamidrazones
- 1 April 2006
- journal article
- research article
- Published by Taylor & Francis Ltd in Phosphorus, Sulfur, and Silicon and the Related Elements
- Vol. 181 (4), 737-744
- https://doi.org/10.1080/10426500500270065
Abstract
The N 1-dithioester substituted pyridin- and pyrazincarboxamidrazones underwent cyclocondensation to 5-methylsulfanyl-1,3,4-thiadiazole or 1,2,4-triazole derivatives, depending on the reaction conditions. With an excess of secondary amines, pyrazincarboxamidrazone dithioester gave 5-amino-1,3,4-thiadiazoles and with an ethanoloamine a 1,2,4-triazole derivative. Prepared compounds were evaluated as potential tuberculostatic agents, but the minimum inhibitory concentrations values indicated no significant activity.Keywords
This publication has 14 references indexed in Scilit:
- Antimycobacterial activity of new 3-substituted 5-(pyridin-4-yl)-3H-1,3,4-oxadiazol-2-one and 2-thione derivatives. Preliminary molecular modeling investigationsBioorganic & Medicinal Chemistry, 2005
- 1,3,4-Thiadiazole Derivatives. Synthesis, Structure Elucidation, and Structure−Antituberculosis Activity Relationship InvestigationJournal of Medicinal Chemistry, 2004
- Synthesis of some 3-(Arylalkylthio)-4-alkyl/aryl-5-(4-aminophenyl)-4H-1,2,4-triazole derivatives and their anticonvulsant activityIl Farmaco, 2004
- Synthesis and antimycobacterial activity of (3,4-diaryl-3H-thiazol-2-ylidene)-hydrazide derivativesIl Farmaco, 2003
- Synthesis and antimycobacterial activity of [5-(pyridin-2-yl)-1,3,4-thiadiazol-2-ylthio]acetic acid arylidene-hydrazide derivativesIl Farmaco, 2001
- Some 3-Thioxo/alkylthio-1,2,4-triazoles with a substituted thiourea moiety as possible antimycobacterialsBioorganic & Medicinal Chemistry Letters, 2001
- NewN1-Hetarylmethylene-Substituted Amidrazones with Potential Antimycobacterial ActivityArchiv der Pharmazie, 1999
- Synthesis of some 3-arylamino-5-aryloxymethyl[1,2,4]triazole derivatives and their antimicrobial activityPharmaceutica Acta Helvetiae, 1998
- In- VitroAntimycobacterial Activity of New Synthetic Amidrazone DerivativesJournal of Chemotherapy, 1993
- Identification of the site of solubilization of various compounds by cetomacrogolJournal of Pharmacy and Pharmacology, 1971