Caspase-10 Negatively Regulates Caspase-8-Mediated Cell Death, Switching the Response to CD95L in Favor of NF-κB Activation and Cell Survival
Open Access
- 1 April 2017
- journal article
- research article
- Published by Elsevier BV in Cell Reports
- Vol. 19 (4), 785-797
- https://doi.org/10.1016/j.celrep.2017.04.010
Abstract
No abstract availableKeywords
Funding Information
- EU Horizon 2020
- Deutsche Forschungsgemeinschaft (Le 953/6-1, 953/8-1)
- Deutsche Forschungsgemeinschaft RTG 2099
- Dietmar Hopp Foundation
- UK Medical Research Council
This publication has 56 references indexed in Scilit:
- A Death Effector Domain Chain DISC Model Reveals a Crucial Role for Caspase-8 Chain Assembly in Mediating Apoptotic Cell DeathMolecular Cell, 2012
- cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP IsoformsMolecular Cell, 2011
- Cellular FLICE-inhibitory Protein (cFLIP) Isoforms Block CD95- and TRAIL Death Receptor-induced Gene Induction Irrespective of Processing of Caspase-8 or cFLIP in the Death-inducing Signaling ComplexOnline Journal of Public Health Informatics, 2011
- Individual caspase-10 isoforms play distinct and opposing roles in the initiation of death receptor-mediated tumour cell apoptosisCell Death & Disease, 2011
- Activation and Specificity of Human Caspase-10Biochemistry, 2010
- Inducible Dimerization and Inducible Cleavage Reveal a Requirement for Both Processes in Caspase-8 ActivationOnline Journal of Public Health Informatics, 2010
- CD95 promotes tumour growthNature, 2010
- FOXO3 Modulates Endothelial Gene Expression and Function by Classical and Alternative Mechanisms*Online Journal of Public Health Informatics, 2010
- Mechanism of procaspase-8 activation by c-FLIP LProceedings of the National Academy of Sciences of the United States of America, 2009
- TRAIL-Induced Apoptosis and Gene Induction in HaCaT Keratinocytes: Differential Contribution of TRAIL Receptors 1 and 2Journal of Investigative Dermatology, 2003