In Vivo Fluorescence Imaging with Ag2S Quantum Dots in the Second Near‐Infrared Region
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- 5 September 2012
- journal article
- research article
- Published by Wiley in Angewandte Chemie
- Vol. 51 (39), 9818-9821
- https://doi.org/10.1002/anie.201206059
Abstract
Hits the dot: Ag2S quantum dots (QDs) with bright near‐infrared‐II fluorescence emission (around 1200 nm) and six‐arm branched PEG surface coating (see scheme) were synthesized for in vivo small‐animal imaging. The 6PEG‐Ag2S QDs afforded a tumor uptake of approximately 10 % injected dose/gram, owing to a long circulation half‐life of approximately 4 h. Clearance of the injected 6PEG‐Ag2S QDs occurs mainly through the biliary pathway in mice.Keywords
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