Proxy‐reported health‐related quality of life of patients with juvenile idiopathic arthritis: The pediatric rheumatology international trials organization multinational quality of life cohort study
Open Access
- 31 January 2007
- journal article
- research article
- Published by Wiley in Arthritis Care & Research
- Vol. 57 (1), 35-43
- https://doi.org/10.1002/art.22473
Abstract
Objective To investigate the proxy‐reported health‐related quality of life (HRQOL) and its determinants in patients with juvenile idiopathic arthritis (JIA). Methods In this multinational, multicenter, cross‐sectional study, HRQOL of patients with JIA was assessed through the Child Health Questionnaire (CHQ) and was compared with that of healthy children of similar age from the same geographic area. Potential determinants of HRQOL included demographic data, physician's and parent's global assessments, measures of joint inflammation, Childhood Health Assessment Questionnaire (CHAQ), and erythrocyte sedimentation rate. Results A total of 6,639 participants (3,324 with JIA and 3,315 healthy) were enrolled from 32 countries. The mean ± SD physical and psychosocial summary scores of the CHQ were significantly lower in patients with JIA than in healthy children (physical: 44.5 ± 10.6 versus 54.6 ± 4.0, P < 0.0001; psychosocial: 47.6 ± 8.7 versus 51.9 ± 7.5, P < 0.0001), with the physical well‐being domain being most impaired. Patients with persistent oligoarthritis had better HRQOL compared with other subtypes, whereas HRQOL was similar across patients with systemic arthritis, polyarthritis, and extended oligoarthritis. A CHAQ score >1 and a pain intensity rating >3.4 cm on a 10‐cm visual analog scale were the strongest determinants of poorer HRQOL in the physical and psychosocial domains, respectively. Conclusion We found that patients with JIA have a significant impairment of their HRQOL compared with healthy peers, particularly in the physical domain. Physical well‐being was mostly affected by the level of functional impairment, whereas the intensity of pain had the greatest influence on psychosocial health.Keywords
This publication has 21 references indexed in Scilit:
- Health-related quality of life of patients with juvenile idiopathic arthritis coming from 3 different geographic areas. The PRINTO multinational quality of life cohort studyRheumatology, 2006
- Development and validation of a clinical index for assessment of long‐term damage in juvenile idiopathic arthritisArthritis & Rheumatism, 2005
- Health‐related quality of life in juvenile‐onset systemic lupus erythematosus and its relationship to disease activity and damageArthritis Care & Research, 2004
- Preliminary definition of improvement in juvenile arthritisArthritis & Rheumatism, 1997
- Measurement of health status in children with juvenile rheumatoid arthritisArthritis & Rheumatism, 1994
- THE FUNCTIONAL AND PSYCHOLOGICAL OUTCOMES OF JUVENILE CHRONIC ARTHRITIS IN YOUNG ADULTHOODRheumatology, 1994
- Cross-cultural adaptation of health-related quality of life measures: Literature review and proposed guidelinesJournal of Clinical Epidemiology, 1993
- Assessment of the reliability and validity of the arthritis impact measurement scales for children with juvenile arthritisArthritis & Rheumatism, 1987
- A study of classification criteria for a diagnosis of juvenile rheumatoid arthritisArthritis & Rheumatism, 1986
- Basic principles of ROC analysisSeminars in Nuclear Medicine, 1978