Simultaneous evaluation of maspin and CXCR4 in patients with breast cancer
- 26 May 2006
- journal article
- Published by BMJ in Journal of Clinical Pathology
- Vol. 60 (3), 261-266
- https://doi.org/10.1136/jcp.2006.037887
Abstract
Aim: To study simultaneously the actions of maspin and CXCR4, which share several similar pathways in cancer, including apoptosis and angiogenesis. Methods: Our material consisted of 151 invasive breast carcinomas arranged in a tissue microarray setting. Maspin and CXCR4 expression was evaluated by immunohistochemistry. Microvessel density was assessed by CD34 immunodetection and apoptosis by the Tdt-mediated dUTP nick end labelling assay. Results: Maspin expression was related to CXCR4 expression, apoptosis, patient age and the Nottingham prognostic index. The expression of both maspin and CXCR4 progressively increased in high-grade tumours. In patients with lymph node negative breast cancer, maspin overexpression was associated with increased risk of death. High CXCR4 expression was associated with prolonged survival of patients with high maspin expression. Conclusions: Our results show that maspin overexpression could prove to be a potentially useful marker, especially for the clinically important group of patients with lymph node negative breast cancer. The expression of CXCR4 is of less significance in our study, but may be informative for specific patient subsets or in a longer time frame.Keywords
This publication has 45 references indexed in Scilit:
- Maspin Mediates Increased Tumor Cell Apoptosis upon Induction of the Mitochondrial Permeability TransitionMolecular and Cellular Biology, 2005
- Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasisThe FASEB Journal, 2004
- Tumor Suppressor Maspin Is Up-Regulated during Keratinocyte Senescence, Exerting a Paracrine Antiangiogenic ActivityCancer Research, 2004
- Regulation of CXCR4-mediated chemotaxis and chemoinvasion of breast cancer cellsOncogene, 2004
- Maspin Expression Is Directly Associated with Biological Aggressiveness of Thyroid CarcinomaThyroid®, 2004
- Expression ofp16INK4A and alterations of the 9p21-23 chromosome region in non-small-cell lung carcinomas: Relationship with tumor growth parameters and ploidy statusInternational Journal of Cancer, 2000
- The myoepithelial defense: a host defense against cancerMedical Hypotheses, 1997
- Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.The Journal of cell biology, 1992
- The Nottingham prognostic index in primary breast cancerBreast Cancer Research and Treatment, 1992
- pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long‐term follow‐upHistopathology, 1991