CD38 expression and complement inhibitors affect response and resistance to daratumumab therapy in myeloma
Top Cited Papers
Open Access
- 18 August 2016
- journal article
- clinical trial
- Published by American Society of Hematology in Blood
- Vol. 128 (7), 959-970
- https://doi.org/10.1182/blood-2016-03-703439
Abstract
Key Points Response to the CD38-targeting antibody daratumumab is significantly associated with CD38 expression levels on the tumor cells. Resistance to daratumumab is accompanied by increased expression of complement-inhibitory proteins.Keywords
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