Isolation of a Galactomannan That Enhances Macrophage Activation from the Edible Fungus Morchella esculenta
- 22 August 2002
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Agricultural and Food Chemistry
- Vol. 50 (20), 5683-5685
- https://doi.org/10.1021/jf020267c
Abstract
The edible mushroom Morchella esculenta is among the most highly prized and morphologically recognizable fungi in the world. We describe the isolation from a polar extract of M. esculenta carpophores of a high-molecular-weight galactomannan, about 1.0 million Da, that exhibits immunostimulatory activity. At 3.0 μg/mL the galactomannan polysaccharide increased NF-kappa B directed luciferase expression in THP-1 human monocytic cells to levels 50% of those achieved by maximal activating concentration (10 μg/mL) of lipopolysaccharide. This galactomannan comprises about 2.0% of the dry fungal material weight, and its glycosyl components include mannose (62.9%) and galactose (20.0%). Keywords: Morchella esculenta; morel; immunostimulatory polysaccharide; galactomannan; THP-1 cells; nuclear factor kappa BThis publication has 3 references indexed in Scilit:
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