Inflammatory Plasma Markers and Pancreatic Cancer Risk: A Prospective Study of Five U.S. Cohorts
- 1 May 2013
- journal article
- Published by American Association for Cancer Research (AACR) in Cancer Epidemiology, Biomarkers & Prevention
- Vol. 22 (5), 855-861
- https://doi.org/10.1158/1055-9965.epi-12-1458
Abstract
Chronic inflammation may play a role in the development of pancreatic cancer. However, few prospective studies have examined the association between plasma inflammatory markers and pancreatic cancer risk. Therefore, we investigated the association of prediagnostic circulating C-reactive protein (CRP), interleukin-6 (IL-6), and TNF-α receptor II (TNF-αR2) with subsequent pancreatic cancer risk in a prospective, nested case–control study of 470 cases and 1,094 controls from Health Professionals Follow-up Study, Nurses' Health Study, Physicians' Health Study, Women's Health Initiative, and Women's Health Study. The median follow-up time of cases was 7.2 years (range 1–26 years). No association was observed between plasma CRP, IL-6, and TNF-αR2 and the risk of pancreatic cancer. Comparing extreme quintiles, the multivariate ORs were 1.10 [95% confidence interval (CI), 0.74–1.63; Ptrend = 0.81] for CRP, 1.19 (95% CI, 0.81–1.76; Ptrend = 0.08) for IL-6, and 0.88 (95% CI, 0.58–1.33; Ptrend = 0.57) for TNF-αR2. In conclusion, prediagnostic levels of circulating CRP, IL-6, and TNF-αR2 were not associated with the risk of pancreatic cancer, suggesting that systemic inflammation as measured by circulating inflammatory factors is unlikely to play a major role in the development of pancreatic cancer. Cancer Epidemiol Biomarkers Prev; 22(5); 855–61. ©2013 AACR.Keywords
This publication has 50 references indexed in Scilit:
- Inflammation marker and risk of pancreatic cancer: a nested case-control study within the EPIC cohortBritish Journal of Cancer, 2012
- Serum C-Reactive Protein and Risk of Pancreatic Cancer in Two Nested, Case–Control StudiesCancer Epidemiology, Biomarkers & Prevention, 2011
- The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancerTrends in Molecular Medicine, 2008
- C-Reactive Protein Levels, Variation in the C-Reactive Protein Gene, and Cancer Risk: The Rotterdam StudyJournal of Clinical Oncology, 2006
- Plasma C-Reactive Protein and Risk of Cancer: A Prospective Study from GreeceCancer Epidemiology, Biomarkers & Prevention, 2006
- Circulating Levels of Inflammatory Markers and Cancer Risk in the Health Aging and Body Composition CohortCancer Epidemiology, Biomarkers & Prevention, 2005
- Low-Dose Aspirin in the Primary Prevention of CancerJama-Journal Of The American Medical Association, 2005
- Final Report on the Aspirin Component of the Ongoing Physicians' Health StudyNew England Journal of Medicine, 1989
- Flexible regression models with cubic splinesStatistics in Medicine, 1989
- Meta-analysis in clinical trialsControlled Clinical Trials, 1986