Regional Cerebral Blood Flow in Man Determined by the Initial Slope of the Clearance of Intra-arterially Injected l33Xe
- 1 November 1971
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Stroke
- Vol. 2 (6), 519-540
- https://doi.org/10.1161/01.str.2.6.519
Abstract
The regional cerebral blood flow can be calculated from the initial slope of the logarithmically displayed clearance curve following intra-arterial injection of 133Xe (rCBFinitial). The relationship between this parameter and the values resulting from stochastic (height over area) and compartmental analyses is extensively discussed. Experimental results demonstrate the theoretically expected close relationship between rCBFinitial and flow of gray substance (rCBFinitial 20% to 30% lower than Fg). It is shown how the cerebral clearance curve (normally biexponential) with low flow values becomes gradually monoexponential. Thus only flow of gray substance changes, whereas flow of white substance is independent of CBF∞. CBF10 was shown to overestimate CBF∞ with about 15% independent of the flow level. Correlation between CBFinitial and CBF10 was linear (r=0.98) at CBF10 values above 20 ml/100 gm/min. The CBFinitial normal value is found to be 64±9 ml/100 gm/min, and the interchannel coefficient of variation is...This publication has 29 references indexed in Scilit:
- NORMAL VALUES OF REGIONAL CEREBRAL BLOOD FLOW IN MAN, INCLUDING FLOW AND WEIGHT ESTIMATES OF GRAY AND WHITE MATTERActa Neurologica Scandinavica, 2009
- CONTRALATERAL FOCAL INCREASE OF CEREBRAL BLOOD FLOW IN MAN DURING ARM WORKBrain, 1971
- The Effects of Paco2 on Regional Cerebral Blood Flow and Internal Carotid Arterial Pressure during Carotid ClampingAnesthesiology, 1971
- The Effect of Intra-arterial Papaverine on the Regional Cerebral Blood Flow in Patients with Stroke or Intracranial TumorStroke, 1971
- Cerebral Blood Flow Measurement as a Safeguard During Carotid EndarterectomyStroke, 1971
- Effect of Pa
CO
CO2 on Blood Flow and Microvasculature of Ischemic and Nonischemic Cerebral CortexStroke, 1970
- Regional blood flow in the normal cerebral hemisphere.Journal of Neurology, Neurosurgery & Psychiatry, 1969
- Effect of alterations in the arterial carbon dioxide tension on the blood flow through the cerebral cortex at normal and low arterial blood pressures.Journal of Neurology, Neurosurgery & Psychiatry, 1965
- The Cerebral Blood Flow in Man Determined by the Use of Radioactive KryptonActa Physiologica Scandinavica, 1955
- THE EFFECTS OF ALTERED ARTERIAL TENSIONS OF CARBON DIOXIDE AND OXYGEN ON CEREBRAL BLOOD FLOW AND CEREBRAL OXYGEN CONSUMPTION OF NORMAL YOUNG MEN 1JCI Insight, 1948