A randomised placebo‐controlled trial to determine the effect of iron supplementation on pregnancy outcome in pregnant women with haemoglobin ≥ 13.2 g/dl
Open Access
- 16 May 2007
- journal article
- research article
- Published by Wiley in BJOG: An International Journal of Obstetrics and Gynaecology
- Vol. 114 (6), 684-688
- https://doi.org/10.1111/j.1471-0528.2007.01325.x
Abstract
To study the effect of iron supplementation on pregnancy outcome in pregnant women with haemoglobin (Hb) > or = 13.2 g/dl. A randomised, double-blind, placebo-controlled trial. Routine health services. Seven hundred and twenty-seven pregnant women with Hb > or = 13.2 g/dl in the early stage of the second trimester. Each woman took one ferrous sulphate [DOSAGE ERROR CORRECTED] tablet (150 g tablet, containing 50 mg of elemental iron) [DOSAGE ERROR CORRECTED] daily in the case group (n = 370) or placebo in the control group (n = 357) throughout pregnancy. Pregnancy outcome. While there were no significant differences in demographic and obstetric characteristics between the two groups before any intervention, small-for-gestational-age birth rate and the number of women with hypertension disorder increased significantly in the case group in comparison with the control group (57 [15.7%] versus 36 [10.3%], P = 0.035, 10 [2.7%] versus 3 [8%], P = 0.05, respectively). Our finding proves that routine iron supplementation in nonanaemic women is not rational and may be harmful.This publication has 15 references indexed in Scilit:
- Effects of alternative maternal micronutrient supplements on low birth weight in rural Nepal: double blind randomised community trialBMJ, 2003
- Maternal Hemoglobin Concentration During Pregnancy and Risk of StillbirthJama-Journal Of The American Medical Association, 2000
- High and low hemoglobin levels during pregnancy: differential risks for preterm birth and small for gestational ageObstetrics & Gynecology, 2000
- Third trimester iron status and pregnancy outcome in non-anaemic women; pregnancy unfavourably affected by maternal iron excess.Human Reproduction, 2000
- Iron needs during pregnancy: do we need to rethink our targets?The American Journal of Clinical Nutrition, 2000
- Significance of an abnormally low or high hemoglobin concentration during pregnancy: special consideration of iron nutritionThe American Journal of Clinical Nutrition, 2000
- Anemia and iron deficiency: effects on pregnancy outcomeThe American Journal of Clinical Nutrition, 2000
- Maternal hemoglobin concentration and birth weightThe American Journal of Clinical Nutrition, 2000
- Long-term follow-up of motherse and their infants in a randomized trial on iron prophylaxis during pregnancyAmerican Journal of Obstetrics and Gynecology, 1995
- RELATION OF HAEMOGLOBIN LEVELS IN FIRST AND SECOND TRIMESTERS TO OUTCOME OF PREGNANCYThe Lancet, 1986