Nervous System Lyme Disease
- 25 November 2014
- journal article
- Published by Springer Science and Business Media LLC in Current Infectious Disease Reports
- Vol. 17 (1), 1-7
- https://doi.org/10.1007/s11908-014-0445-6
Abstract
Lyme disease, a multisystem spirochetal infection, continues to be the subject of considerable debate, but not controversy. Recent years have seen improvements in diagnostic tools, better understanding of pathophysiology, and increasing evidence of efficacy of standard treatment regimens. Nervous system involvement is particularly confusing to patients and many physicians. A rational approach based on objective findings can clarify the cause and dictate the best treatment of patients’ difficulties. Diagnosis for all but the earliest cases rests on the combination of likely contact with infected Ixodes ticks and laboratory confirmation of exposure to the causative organism, Borrelia burgdorferi (two-tier serology, combining ELISA with a confirmatory Western blot). Treatment is generally with oral antimicrobials such as doxycycline. Parenteral regimens are usually necessary only for the most severe cases.Keywords
This publication has 45 references indexed in Scilit:
- Cerebrospinal fluid CXCL13 in Lyme neuroborreliosis and asymptomatic HIV infectionBMC Neurology, 2013
- Nervous system Lyme diseaseJournal of the Royal College of Physicians of Edinburgh, 2010
- The chemokine CXCL13 is a key regulator of B cell recruitment to the cerebrospinal fluid in acute Lyme neuroborreliosisJournal of Neuroinflammation, 2009
- Practice Parameter: Treatment of nervous system Lyme disease (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of NeurologyNeurology, 2007
- Facial nerve palsy associated with lyme diseaseMuscle & Nerve, 2003
- Borrelia burgdorferi ‐specific intrathecal antibody production in neuroborreliosisNeurology, 1993
- Lyme neuroborreliosis: A new sensitive diagnostic assay for intrathecal synthesis of borrelia burgdorferi–specific immunoglobulin G, A, and MAnnals of Neurology, 1991
- Spirochetes Isolated from the Blood of Two Patients with Lyme DiseaseThe New England Journal of Medicine, 1983
- The Spirochetal Etiology of Lyme DiseaseThe New England Journal of Medicine, 1983
- Chronische lymphocytäre Meningitis, entzündliche Polyneuritis und „Rheumatismus”Archiv Fur Psychiatrie Und Nervenkrankheiten, 1941