Fibrillary Glomerulonephritis with Hepatitis C Viral Infection and Hypocomplementemia
Open Access
- 1 January 2008
- journal article
- case report
- Published by Informa UK Limited in Renal Failure
- Vol. 30 (7), 759-762
- https://doi.org/10.1080/08860220802213062
Abstract
Fibrillary glomerulonephritis (FGN) is a relatively rare cause of renal disease, found in only 0.6–1.5% of native renal biopsies. The pathogenesis of FGN is not well described, and very few associations with disease processes other than hepatitis C virus (HCV) have been made. We describe a case that provides evidence in support of the FGN-HCV association, as well as introduces the association of FGN-HCV and hypocomplementemia. The case is a 53-year-old African-American female demonstrating a classical presentation of FGN complicated by a concomitant HCV infection. Treating an HCV infection with alpha-interferon has been shown to result in subsequent improvement in the nephrotic syndrome and renal function. However, this patient is unique in that she is complicated with hypocomplementemia, creating a complex treatment situation.Keywords
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