An Adduct between Peroxynitrite and 2‘-Deoxyguanosine: 4,5-Dihydro-5-hydroxy-4-(nitrosooxy)-2‘-deoxyguanosine
- 1 January 1996
- journal article
- Published by American Chemical Society (ACS) in Chemical Research in Toxicology
- Vol. 9 (1), 3-7
- https://doi.org/10.1021/tx950126n
Abstract
The reactivity of peroxynitrite (OONO-) with DNA is of interest because it is released during chronic inflammation, a major contributor to cancer. Peroxynitrite was found to undergo homolytic addition to the C4−C5 double bond of 2‘-deoxyguanosine with formation of 4,5-dihydro-5-hydroxy-4-(nitrosooxy)-2‘-deoxyguanosine (nox-dG). This adduct may be a useful marker in the study of the chemical processes associated with the mutagenicity of peroxynitrite.Keywords
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