Recent advances in understanding the molecular basis of group BStreptococcusvirulence

Abstract

Group BStreptococcuscommonly colonises healthy adults without symptoms, yet under certain circumstances displays the ability to invade host tissues, evade immune detection and cause serious invasive disease. Consequently, Group BStreptococcusremains a leading cause of neonatal pneumonia, sepsis and meningitis. Here we review recent information on the bacterial factors and mechanisms that direct host–pathogen interactions involved in the pathogenesis of Group BStreptococcusinfection. New research on host signalling and inflammatory responses to Group BStreptococcusinfection is summarised. An understanding of the complex interplay between Group BStreptococcusand host provides valuable insight into pathogen evolution and highlights molecular targets for therapeutic intervention.