Excess thymidine induces folate sensitve fragile sites
- 1 October 1985
- journal article
- research article
- Published by Wiley in American Journal of Medical Genetics
- Vol. 22 (2), 433-443
- https://doi.org/10.1002/ajmg.1320220234
Abstract
Folate sensitive fragile sites on human chromosomes have been found to be inducible in cultured lymphocytes by high levels of thymidine but not by high levels of BrdU. The biochemical interpretation of events leading to fragile site expression has been revised since it is now clear that low levels of either thymidylate or deoxycytidine triphosphate will result in this phenomenon. A model for the DNA at a fragile site, composed of alternating repeating polypurine/polypyrimidine sequences is proposed.Keywords
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