Relationship Between NMO-Antibody and Anti–MOG Antibody in Optic Neuritis
- 1 June 2012
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of Neuro-Ophthalmology
- Vol. 32 (2), 107-110
- https://doi.org/10.1097/wno.0b013e31823c9b6c
Abstract
Damage to astrocytes by anti-aquaporin-4 antibody (AQP4-Ab), also known as NMO antibody, has been implicated as the cause of neuromyelitis optica. Myelin oligodendrocyte glycoprotein (MOG) is well known as the causative protein of multiple sclerosis (MS). MOG antigen is currently considered as a cause of optic neuritis (ON) associated with MS because immunization with MOG antigen derived from oligodendrocytes induces murine ON with myelitis. We investigated the relationship between NMO antibody (NMO-Ab) and anti-MOG antibody (MOG-Ab) and potential in patients with ON for recovery of vision. Thirty-three eyes of 23 patients with ON were studied. At presentation, serum NMO-Ab was measured by immunofluorescence using HEK 293 cells transfected with AQP4–GFP, and anti-MOG1–125 antibody was measured by enzyme-linked immunosorbent assay. MOG-Ab seropositivity was defined by comparing with MOG-Ab level obtained from 8 healthy normal subjects. Eleven (47%) of 23 ON patients were NMO-Ab seropositive, while 8 (34%) of the 23 patients were MOG-Ab seropositive. Six (26%) of 23 patients were seropositive for both NMO-Ab and MOG-Ab. Ten (43%) of 23 patients were seronegative for both antibodies. Three (50%) of 6 eyes of patients seropositive for both antibodies did not respond to corticosteroid pulse therapy and plasmapheresis, and visual acuity remained unchanged. In the NMO-Ab(−)/MOG-Ab(−) group, visual acuity improved significantly (P < 0.0001). In the other 3 groups (NMO-Ab(+)/MOG-Ab(+), NMO-Ab(+)/MOG-Ab(−), and NMO-Ab(−)/MOG-Ab(+)), visual acuity did not change significantly (P = 0.53, 0.42, and 0.45, respectively). NMO-Ab and MOG-Ab could be potential biomarkers to determine visual prognosis in patients with ON.Keywords
This publication has 22 references indexed in Scilit:
- Antibody to aquaporin-4 in the long-term course of neuromyelitis opticaBrain, 2008
- NMO-IgG predicts the outcome of recurrent optic neuritisNeurology, 2008
- Neuromyelitis optica pathogenesis and aquaporin 4Journal of Neuroinflammation, 2008
- Pathogenic potential of IgG binding to water channel extracellular domain in neuromyelitis opticaNeurology, 2007
- Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured proteinNature Medicine, 2007
- IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channelThe Journal of Experimental Medicine, 2005
- Frontline: Epitope recognition on the myelin/oligodendrocyte glycoprotein differentially influences disease phenotype and antibody effector functions in autoimmune demyelinationEuropean Journal of Immunology, 2004
- Reactivity to myelin antigens in multiple sclerosis. Peripheral blood lymphocytes respond predominantly to myelin oligodendrocyte glycoprotein.JCI Insight, 1993
- Purification and Partial Structural and Functional Characterization of Mouse Myelin/Oligodendrocyte GlycoproteinJournal of Neurochemistry, 1992
- Antibody responses in chronic relapsing experimental allergic encephalomyelitis: correlation of serum demyelinating activity with antibody titre to the myelin/oligodendrocyte glycoprotein (MOG)Journal of Neuroimmunology, 1987