FDG PET/CT is useful for detecting infiltration to the port site in patients with malignant pleural mesothelioma
- 27 November 2013
- journal article
- Published by Springer Science and Business Media LLC in General Thoracic and Cardiovascular Surgery
- Vol. 62 (3), 157-162
- https://doi.org/10.1007/s11748-013-0345-y
Abstract
One reason for the poor outcomes of multimodality therapies, including macroscopic complete resection, in patients with malignant pleural mesothelioma (MPM) is the difficulty of correctly staging the disease, which can result in incomplete resection. The purpose of this study was to investigate the aspects of tumor infiltration to the port site and the usefulness of preoperative FDG PET/CT for diagnosing MPM. Between June 2007 and May 2013, 21 patients who underwent surgical treatment with curative intent for MPM that had been previously diagnosed on a video-assisted thoracic surgery (VATS) biopsy were included in this study. There were 17 males and four females, with a mean age of 63 years. The accumulation of FDG at the port site was observed in all nine patients with tumor infiltration to the port site, whereas this feature was not noted in 15 patients without tumor extension to the port site. There were more positive lymph node cases in the infiltration group than in the non-infiltration group (p = 0.02). No significant differences in survival were observed between the patients with and without tumor infiltration to the port site. FDG PET/CT is useful for detecting tumor infiltration of MPM to the port site and may help to prevent local recurrence, especially port site relapse, following macroscopic complete resection. However, this condition is related to tumor aggressiveness; therefore, performing careful staging and determining the appropriate treatment strategy are required in such patients.Keywords
This publication has 14 references indexed in Scilit:
- Guidelines for Pathologic Diagnosis of Malignant Mesothelioma: 2012 Update of the Consensus Statement from the International Mesothelioma Interest GroupArchives Of Pathology & Laboratory Medicine, 2013
- Factors predicting poor survival after lung-sparing radical pleurectomy of IMIG stage III malignant pleural mesotheliomaEuropean Journal of Cardio-Thoracic Surgery, 2012
- Initial Analysis of the International Association For the Study of Lung Cancer Mesothelioma DatabaseJournal of Thoracic Oncology, 2012
- Continued pemetrexed and platin-based chemotherapy in patients with malignant pleural mesothelioma (MPM): Value of 18F-FDG-PET/CTEuropean Journal of Radiology, 2012
- Extra-pleural pneumonectomy versus no extra-pleural pneumonectomy for patients with malignant pleural mesothelioma: clinical outcomes of the Mesothelioma and Radical Surgery (MARS) randomised feasibility studyThe Lancet Oncology, 2011
- Multicenter Phase II Trial of Neoadjuvant Pemetrexed Plus Cisplatin Followed by Extrapleural Pneumonectomy and Radiation for Malignant Pleural MesotheliomaJournal of Clinical Oncology, 2009
- Integrated computed tomography-positron emission tomography in patients with potentially resectable malignant pleural mesothelioma: Staging implicationsThe Journal of Thoracic and Cardiovascular Surgery, 2005
- Positron emission tomography defines metastatic disease but not locoregional disease in patients with malignant pleural mesotheliomaThe Journal of Thoracic and Cardiovascular Surgery, 2003
- Assessment of malignant pleural mesothelioma with (18)F-FDG dual-head gamma-camera coincidence imaging: comparison with histopathology.2002
- A Proposed New International TNM Staging System for Malignant Pleural MesotheliomaSocial psychiatry. Sozialpsychiatrie. Psychiatrie sociale, 1995