Independent associations of serum concentrations of 25-hydroxyvitamin D and parathyroid hormone with blood pressure among US adults
- 1 September 2010
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal Of Hypertension
- Vol. 28 (9), 1821-1828
- https://doi.org/10.1097/hjh.0b013e32833bc5b4
Abstract
Vitamin D deficiency or high levels of parathyroid hormone (PTH) appear to be emerging risk factors for hypertension. This study examined whether serum concentrations of 25-hydroxyvitamin D [25(OH)D] and PTH were independently associated with blood pressure and the presence of hypertension or prehypertension among the United States adults. Cross-sectional data from 7228 participants (aged ≥20 years) in the 2003–2006 National Health and Nutrition Examination Survey were analyzed. The least square means and the regression coefficients of systolic blood pressure, diastolic blood pressure, and pulse pressure across quintiles of serum 25(OH)D and PTH were estimated by conducting multiple linear regression analyses. The adjusted prevalence ratios with 95% confidence intervals for hypertension and prehypertension were estimated using the log-binomial method. Among participants not taking blood pressure medications (n = 5414), the mean age- and sex-adjusted systolic and diastolic blood pressure decreased linearly across quintiles of serum 25(OH)D but increased linearly across quintiles of serum PTH (P Conclusion Serum concentrations of 25(OH)D and PTH were independently associated with blood pressure and with the presence of hypertension or prehypertension among the United States adults, though casual relationships remain to be elucidated.Keywords
This publication has 51 references indexed in Scilit:
- Vitamin D and Cardiovascular DiseasePharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2009
- Plasma 25-Hydroxyvitamin D Levels and Risk of Incident Hypertension Among Young WomenHypertension, 2008
- Vitamin D and blood pressure connection: update on epidemiologic, clinical, and mechanistic evidencePublished by Oxford University Press (OUP) ,2008
- Optimal vitamin D status attenuates the age-associated increase in systolic blood pressure in white Americans: results from the third National Health and Nutrition Examination SurveyThe American Journal of Clinical Nutrition, 2008
- Serum 25-hydroxyvitamin D, Ethnicity, and Blood Pressure in the Third National Health and Nutrition Examination SurveyAmerican Journal of Hypertension, 2007
- Prevalence of Cardiovascular Risk Factors and the Serum Levels of 25-Hydroxyvitamin D in the United StatesArchives of Internal Medicine, 2007
- Plasma 25-Hydroxyvitamin D Levels and Risk of Incident HypertensionHypertension, 2007
- Association of Calcitriol and Blood Pressure in Normotensive MenHypertension, 1997
- Vitamin D is related to blood pressure and other cardiovascular risk factors in middle-aged menAmerican Journal of Hypertension, 1995
- Relationship between Vitamin D3 and the Peripheral Circulation in Moderate Arterial Primary HypertensionBlood Pressure, 1994