Reversal of One-Kidney, One-Clip Hypertension by Unclipping: The Renal, Sodium-Volume Relationship Reexamined

Abstract

Summary The kidney exerts an antihypertensive function that appears, in part, to countervail the prohypertensive actions of Na-volume loads. This function seems to require a normal, or near normal, renal hemodynamic state. The time course for this renal action is dependent on the state of the body fluids, rapid with contracted body fluids, intermediate with normal body fluids, and prolonged with body fluid expansion. The similarities in the antihypertensive action of UCA and transplants of RIC suggest a commonality of action between these procedures. It is suggested that the common denominator between these procedures is the antihypertensive action of the RIC. The mediator(s) of this action is unknown. The most prominent candidate(s) for the mediation are lipids extracted from renal medulla and cultured RIC.