Cell Signals Influencing Hepatic Fibrosis
Open Access
- 1 January 2012
- journal article
- review article
- Published by Hindawi Limited in International Journal of Hepatology
- Vol. 2012, 1-18
- https://doi.org/10.1155/2012/158547
Abstract
Liver fibrosis is the result of the entire organism responding to a chronic injury. Every cell type in the liver contributes to the fibrosis. This paper first discusses key intracellular signaling pathways that are induced during liver fibrosis. The paper then examines the effects of these signaling pathways on the major cell types in the liver. This will provide insights into the molecular pathophysiology of liver fibrosis and should identify therapeutic targets.Keywords
Funding Information
- National Institutes of Health (GM41804, AA15055, DK72237, AI077780, NIH RO1 DK090962-01, NIH RO1 DK072237-06, NIH RO1 GM041804-24, NIH P50 AA011999-13)
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