Maximum Likelihood Ratio Tests for Comparing the Discriminatory Ability of Biomarkers Subject to Limit of Detection
- 28 November 2007
- journal article
- research article
- Published by Oxford University Press (OUP) in Biometrics
- Vol. 64 (3), 895-903
- https://doi.org/10.1111/j.1541-0420.2007.00941.x
Abstract
Summary In this article, we consider comparing the areas under correlated receiver operating characteristic (ROC) curves of diagnostic biomarkers whose measurements are subject to a limit of detection (LOD), a source of measurement error from instruments' sensitivity in epidemiological studies. We propose and examine the likelihood ratio tests with operating characteristics that are easily obtained by classical maximum likelihood methodology.Keywords
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