HLA-F and MHC-I Open Conformers Cooperate in a MHC-I Antigen Cross-Presentation Pathway
Open Access
- 15 August 2013
- journal article
- Published by The American Association of Immunologists in The Journal of Immunology
- Vol. 191 (4), 1567-1577
- https://doi.org/10.4049/jimmunol.1300080
Abstract
Peptides that are presented by MHC class I (MHC-I) are processed from two potential sources, as follows: newly synthesized endogenous proteins for direct presentation on the surface of most nucleated cells and exogenous proteins for cross-presentation typically by professional APCs. In this study, we present data that implicate the nonclassical HLA-F and open conformers of MHC-I expressed on activated cells in a pathway for the presentation of exogenous proteins by MHC-I. This pathway is distinguished from the conventional endogenous pathway by its independence from TAP and tapasin and its sensitivity to inhibitors of lysosomal enzymes, and further distinguished by its dependence on MHC-I allotype-specific epitope recognition for Ag uptake. Thus, our data from in vitro experiments collectively support a previously unrecognized model of Ag cross-presentation mediated by HLA-F and MHC-I open conformers on activated lymphocytes and monocytes, which may significantly contribute to the regulation of immune system functions and the immune defense.Keywords
This publication has 64 references indexed in Scilit:
- Cross-presentation by dendritic cellsNature Reviews Immunology, 2012
- MHC Class I Endosomal and Lysosomal Trafficking Coincides with Exogenous Antigen Loading in Dendritic CellsPLOS ONE, 2008
- MHC class I assembly: out and aboutTrends in Immunology, 2008
- The known unknowns of antigen processing and presentationNature Reviews Immunology, 2008
- Bystander B cells rapidly acquire antigen receptors from activated B cells by membrane transferProceedings of the National Academy of Sciences of the United States of America, 2008
- Antigen presentation by monocytes and monocyte-derived cellsCurrent Opinion in Immunology, 2007
- Gap junction channel structure in the early 21st century: facts and fantasiesCurrent Opinion in Cell Biology, 2007
- An Intracellular Serpin Regulates Necrosis by Inhibiting the Induction and Sequelae of Lysosomal InjuryCell, 2007
- Structural basis for recognition of the nonclassical MHC molecule HLA-G by the leukocyte Ig-like receptor B2 (LILRB2/LIR2/ILT4/CD85d)Proceedings of the National Academy of Sciences, 2006
- Activation of NK Cells by an Endocytosed Receptor for Soluble HLA-GPLoS Biology, 2005