Coupled dynamics of voltage and calcium in paced cardiac cells
- 8 February 2005
- journal article
- research article
- Published by American Physical Society (APS) in Physical Review E
- Vol. 71 (2), 021903
- https://doi.org/10.1103/physreve.71.021903
Abstract
We investigate numerically and analytically the coupled dynamics of transmembrane voltage and intracellular calcium cycling in paced cardiac cells using a detailed physiological model, and its reduction to a three-dimensional discrete map. The results provide a theoretical framework to interpret various experimentally observed modes of instability ranging from electromechanically concordant and discordant alternans to quasiperiodic oscillations of voltage and calcium.Keywords
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