Biotransformation of Malachite Green by the FungusCunninghamella elegans
Open Access
- 1 September 2001
- journal article
- Published by American Society for Microbiology in Applied and Environmental Microbiology
- Vol. 67 (9), 4358-4360
- https://doi.org/10.1128/aem.67.9.4358-4360.2001
Abstract
The filamentous fungusCunninghamella elegansATCC 36112 metabolized the triphenylmethane dye malachite green with a first-order rate constant of 0.029 μmol h−1(mg of cells)−1. Malachite green was enzymatically reduced to leucomalachite green and also converted to N-demethylated and N-oxidized metabolites, including primary and secondary arylamines. Inhibition studies suggested that the cytochrome P450 system mediated both the reduction and the N-demethylation reactions.Keywords
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