Synthesis and Radical Cyclization of 2-Allylamino-3-chloropropylphenyl Sulfones to 2,4-Disubstituted Pyrrolidines

Abstract

Allylic and propargylic amines give a chemoselective conjugate addition to 3-chlorovinyl sulfones under appropriate conditions. The resulting allylamino sulfones are cyclized using tributyltin hydride to afford 2,4-disubstituted pyrrolidines in satisfactory yield.