A new cytotoxic and larvicidal himachalenoid, rosanoids and other constituents ofHugonia busseana
- 28 August 2007
- journal article
- research article
- Published by Taylor & Francis Ltd in Natural Product Research
- Vol. 21 (11), 1027-1031
- https://doi.org/10.1080/14786410701371074
Abstract
A new cytotoxic himachalene sesquiterpenoid 4α-methoxy-5,9-oxahimachal-9-ene (hugonianene A) which exhibited moderate activity against Anopheles gambiae mosquito larvae after 24 h at a concentration of 0.237 mg mL−1, and at 48 h and 72 h contact time causing complete larval mortality up to a concentration as low as 0.01369 mg mL−1, was isolated as the major constituent of the cytotoxic root bark extract of Hugonia busseana. Hugonianene A was obtained together with the hitherto unreported rosane diterpenoid 18-hydroxyrosane, the known rosane diterpenoid hugorosediol, an inseparable mixture of 12-methoxy-13-methylpodocarpa-8,11,13-trien-3,7-dione and 12-methoxy-13-methylpodocarpa-1,8,11,13-tetraen-3,7-dione, and the di-podocarpanoid hugonone B that was previously obtained from H. castaneifolia.Keywords
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